USPSTF Releases Draft Recommendations for PSA Testing

With the release of a new draft document, the U.S. Preventative Services Task Force (USPSTF) has proposed a change in its stance on the advisability of PSA prostate cancer screening for men ages 55 to 69. The new recommendations are based on evidence that supports some benefit to such screenings for the early detection of aggressive prostate cancer. However, the USPSTF also acknowledges offsetting harms from the invasive testing and treatment that may follow a positive PSA screen.

USPSTF Draft of Updated Recommendation on Prostate Cancer Screening

The USPSTF draft document details proposed revisions to the 2012 recommendations concerning prostate-specific antigen (PSA) screenings for prostate cancer. These recommendations revise the USPSTF grades assigned to the use of routine PSA-based prostate cancer screening in two age categories:

  1. Men ages 55 to 69 years
  2. Men ages 70 years & older

The previous grade for both age groups was “D,” recommending against such routine screening. The new draft recommendation retains the “D” designation for men 70 and older but revises the grade to “C” for men in the younger category.

Informed Decision-Making by Individual Patients

The USPSTF makes recommendations on the effectiveness of preventative care services such as PSA prostate cancer screening based on evidence of both benefit and harm. For men 55 to 69 years, the proposed grade of “C” indicates a balance between potential benefit from early cancer detection and the possible harmful outcomes that may result from screening. These include:

  • False-positive results leading to additional testing
  • Overdiagnosis & overtreatment
  • Treatment complications

The USPSTF urges clinicians to discuss the advantages and potential risks of PSA screening with their patients, so individuals in the 55 to 69 age category have the information they need to make an informed decision about proceeding with PSA testing.

Limited Potential Benefits from Standard PSA Screening

Although prostate cancer is one of the most common cancers in men, not all prostate cancers are aggressive or likely to metastasize. Some men who have been screened and identified as having cancer showed no symptoms and may not have been aware of the condition if they had not been screened. Autopsies performed on men who died of other causes reveal an incidence of prostate cancer by age group of:

  • 25% for men ages 55 to 69
  • 33% for men ages 70 & over

The USPSTF has found adequate data from random clinical trials that screening may prevent some cases of metastasized cancer deaths: up to three cases per 1000 men (55 to 69 years of age) screened over a 13-year period. The draft recommendation notes that PSA screening is ineffective at distinguishing between aggressive cancers that are likely to metastasize and cancer that either does not progress or progresses so slowly that the patient never experiences symptoms. The proposed recommendation also notes that further research is needed for developing and studying different diagnostic tests and protocols.

False-Positive Cancer Diagnosis & Overdiagnosis

According to the draft recommendation of the USPSTF, the potential benefit of routine PSA screening for men ages 55 to 69 is offset by these severe shortcomings in test interpretation:

  • Conditions like an enlarged prostate (benign prostatic hyperplasia) and inflammation of the prostate (prostatitis) also deliver elevated PSA readings. A false-positive PSA reading puts men at risk for side effects and complications from further diagnostic testing procedures.
  • A positive PSA screening result may lead to overdiagnosis and overtreatment of cancer in men whose prostate cancer would never have become symptomatic while they lived. In such cases, these men would receive no benefit from treatment. The USPSTF draft cites large randomized trials that indicate that 20% to 50% of men diagnosed with prostate cancer through screening may represent overdiagnosis of the condition.1

Harmful Outcomes from Additional Diagnostic Tests & Overtreatment

According to the USPSTF draft document, there is adequate evidence that further diagnostic testing and cancer treatment may result in a moderate chance of harm. Additional testing and biopsy due to false-positive PSA results may include pain, infection, hematospermia (blood in semen or ejaculate), and complications severe enough to require hospitalization. Men undergoing prostate cancer treatment are also subject to unpleasant health and lifestyle side effects including long-term sexual impotence, urinary incontinence, and bowel urgency or bowel incontinence.

USPSTF Grade-Change Considerations

Data from random trials, cohort studies and decision analysis models reviewed by USPSTF support the conclusion that the benefit of PSA-based screening for men ages 55 to 69 depends on the value judgments of individual men. Although PSA screening has the potential for early detection and treatment that may save lives, that potential is balanced by the possibility of overdiagnosis, false-positive indications, and complications of treatment that could affect quality of life.

USPSTF’s recommended grade change to “C” for men in the younger screening age group is an acknowledgment that men should have an opportunity to make informed decisions about PSA screening results and the need for further tests or treatments following a positive result. The draft proposal also provides study information for men with a higher risk of developing prostate cancer, including African American men and men with a family history of the disease. The USPSTF supports the role of the clinician in providing updated, evidence-based information and providing all groups with the full picture for making decisions about PSA-based prostate cancer screening.


1  Fenton JJ, Weyrich MS, Durbin S, Liu Y, Bang H, Melnikow J. Prostate-Specific Antigen-Based Screening for Prostate Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 154. AHRQ Publication No. 17-05229-EF-1. Rockville, MD: Agency for Healthcare Research and Quality; 2017.

Coping With a Prostate Cancer Diagnosis

If you’ve received a recent prostate cancer diagnosis, it’s normal to feel numb, grief-stricken, shocked or angry as you process the reality that cancer is now part of your story. Though all these reactions are normal, they can slowly drain your emotional and mental energy if you allow them to consume you. To understand clinical recommendations and make informed choices about prostate cancer treatment, you first need to deal constructively with the thoughts and feelings that threaten to overwhelm you.       

What Does Constructive Coping Look Like?  

Everyone copes in his own way, and it takes time and practice to recalibrate your thoughts and find your equilibrium after a cancer diagnosis. As you work through this process, try incorporating these coping methods:

  • Be informed & proactive. Prostate cancer can send you reeling. For many men, reestablishing a healthy sense of control is the first step to making peace with a diagnosis. Begin by asking questions, drawing from clinical resources and taking time to research what your results mean—and what options you have. Depending on your family history, PSA, Gleason score and 4Kscore results, your cancer care team can help you develop a treatment strategy tailored to you. Possible treatments may include watchful surveillance, surgery or radiation therapy.
  • Draw strength from community. Though you may want to avoid people or withdraw into yourself after a prostate cancer diagnosis, it is painful to handle the journey on your own. If you are not comfortable with a traditional support group format, consider a health and wellness Meetup group. Your gym or local hospital may also host community wellness programs that blend camaraderie, fitness and education. With over 170 worldwide locations, the Cancer Support Community offers workshops, online forums and recreational programs where prostate cancer survivors receive social and emotional support throughout all stages of their disease.
  • Create a holistic self-care plan. It’s easy to focus on the physical part of prostate cancer treatment, but remember that emotional and spiritual well-being also factor into an effective self-care strategy. Pursue balance in the form of healthy eating, positive sleep habits, recommended exercise, and meditation or relaxation techniques. While there is no single right way to eat, exercise or feel better, working with a multi-disciplinary team of dietitians, social workers, spiritual advisors and physical therapists can help you make the best decisions.
  • Maintain normalcy. When your world seems upside down, there’s something to be said for routine. Taking life one day (or moment) at a time, do your best to pursue your career, engage in hobbies, and enjoy time with family and friends—with the understanding that you may need to modify from time to time. Continually remind yourself that cancer doesn’t define you, even when it seems ever-present.

Stay Informed With 4Kscore

This year alone, the American Cancer Society reports that more than 160,000 American men will deal with a prostate cancer diagnosis [1] and weather its impact on their lives, families and careers. Subscribe to the 4Kscore blog to learn more about advances in the world of prostate cancer testing.

  • American Cancer Society. Key Statistics for Prostate Cancer. (Access Sept. 15, 2017)

Prostate Cancer Awareness is on the Rise

Prostate cancer impacts millions of lives around the world each year. In fact, 1 in 7 men will be diagnosed with prostate cancer during his lifetime. [1] Like most health conditions, public awareness is key in the fight against prostate cancer. Each year more and more celebrities, athletes and organizations join in the cause to raise prostate cancer awareness, an effort which touches the lives of those impacted by the disease.

Celebrities Committed to Raising Prostate Cancer Awareness

Ed Randall

Ed Randall is a famous television personality who became a household name with his show Ed Randall’s Talking Baseball. The show aired nationally from 1988 to 2002. Some of his most famous interviews included Mickey Mantle, Yogi Berra, Ernie Banks, Bob Gibson, Harry Caray and actor Bill Murray.

Today Mr. Randall is the CEO and Founder of Ed Randall’s Fans for the Cure (FFTC). Established in 2003, FFTC has since host more than 1,500 prostate cancer awareness days/nights at major league and minor league ballparks throughout the country. Ed also travels the US hosting town halls with survivors, physician and policy makers, sparking conversation about how to most effectively diagnose and fight the disease. Learn more about FFTC at their official website: [2]

Harry Belafonte

Beloved musician Harry Belafonte is accredited with popularizing calypso music. Today his name has also become synonymous with the effort to raise prostate cancer awareness. Mr. Belafonte was diagnosed at the age of 69. After undergoing treatment, Belafonte set out to ignite conversation around the impact of the disease and the importance of early detection. Much of his work has focused on raising awareness in the African American community and dispelling the stigma of undergoing prostate examination. [3]

Ben Stiller

When you hear the name Ben Stiller, plenty of things come to mind. The famous comedian, actor and filmmaker has stared in a host of iconic comedies since he first began his Hollywood career nearly 3 decades ago. Today Ben is not only a star, but he is a husband and a father who has most recently made headlines as an advocate of early prostate cancer detection. Ben made headlines just last year when he spoke out about his 2014 prostate cancer diagnosis and encouraged others to take an active role in monitoring their prostate health. [4]

Organizations Supporting Prostate Cancer Awareness & Research

Major League Baseball

Major League Baseball has partnered with the Prostate Cancer Foundation to host the annual PCF Home Run Challenge. The annual event brings together the biggest names in baseball to raise money for research. Monetary pledges are made based upon the number of home runs hit throughout the week leading up to Father’s Day. Since the inception of the PCF Home Run Challenge in 1997, it has raised more than $40 million for prostate cancer research. Visit to access a schedule and to make a pledge. [5]

This is just a small sampling of the growing list of personalities and organizations who are joining the cause. As we celebrate Prostate Cancer Awareness month this September, we encourage you to watch for messaging from these individuals and organizations, as well as others joining in the conversation. While you’re at it, do your part to shed light on the topic. Share information about the importance of raising public awareness and early detection. Together we can make a difference.


  • American Cancer Society. Key Statistics for Prostate Cancer. (Access August 7, 2017)
  • Fans for the Cure. About Us; Ed Randall. (Access August 7, 2017)
  • Harry Belafonte Speaks Up Against Prostate Cancer. (Access August 7, 2017)
  • Ben Stiller: Prostate Cancer Test ‘Save My Live.’ (Access August 7, 2017)
  • Prostate Cancer Foundation. Support Our Partners. (Access August 7, 2017)


Why is it Important to Know if I have Aggressive Prostate Cancer?

Prostate Cancer is the second leading cause of cancer death in men in the United States. In fact, it is estimated that 26,120 men will die of prostate cancer in 2017 alone. [1] While these figures are alarming, not all forms of prostate cancer are equally dangerous.  Those types of prostate cancer that are indolent and unlikely to spread have good survival rates, with 5-year survival of [2]:

  • Localized prostate cancer 100%
  • Regional prostate cancer 100%
  • Distant metastatic prostate cancer 29.8%
  • Unstaged prostate cancer 81.2%

Aggressive vs Low Grade Prostate Cancer

Low-grade prostate cancers are generally considered to be non-life threatening, and in many cases the patient may not even require treatment. Physicians often recommend patients with low-grade prostate cancer (Gleason Score = 6) simply be monitored with active surveillance. Prostate cancers with a Gleason Score ranging between 7 and 10, however, are considered aggressive and may be life threatening. In many cases, those men diagnosed with aggressive prostate cancer can benefit from and should receive early treatment.

Detecting Aggressive Prostate Cancer

The PSA test is a widely-used blood test designed to detect Prostate-Specific Antigens (PSA) in the bloodstream. Though an elevated PSA level can be indicative of a higher risk level of developing prostate cancer, it does not effectively differentiate between prostate cancer and other less serious health conditions. Oftentimes, an elevated PSA score does not indicate the presence of prostate cancer.

The 4Kscore is a blood test performed after an abnormal PSA that provides men with an accurate risk of having aggressive prostate cancer, and categorizes their risk of developing distant metastasis for over 10 years. [3, 4] It combines four prostate protein levels and clinical findings to provide a risk score for aggressive prostate cancer, which can then be used by men and their doctors in the biopsy decision making process.

By providing the risk of aggressive prostate cancer after an abnormal PSA, the 4Kscore is revolutionizing the way physicians and patients approach prostate cancer diagnosis. As a result, men with a low risk can avoid an unnecessary prostate biopsy, while higher risk men can get the appropriate evaluation and treatment. [5]

How do you know if you have aggressive prostate cancer?

Ready to Learn More About the 4Kscore?

At GenPath and BioReference, OPKO Health Companies, we often hear from both physicians and patients interested in learning more about the 4Kscore Test. If you are a physician interested in offering the 4Kscore Test to your patients, contact us today. Begin offering the 4Kscore Test in your practice and join our physician locater tool. If you are a patient who would like to encourage your physician to begin offering the 4Kscore Test, reach out to us. Together we can save lives!

Are you interested in learning more about prostate health? Subscribe to our blog and connect with us on Facebook, Twitter, Google+ and LinkedIn. Join in the conversation!


[1] Prostate Cancer: Statistics. Available at (Accessed on April 5, 2017).

[2] NIH: Cancer Stat Facts: Prostate Cancer. Available at (Access August 1, 2017)

[3] Parekh DJ, Punnen Sm, Sjoberg DDm et al. A Multi-institutional Prospective Trial in the USA Confirms that the 4Kscore Accurately Identifies Men with High-grade Prostate Cancer. Eur Urol. 2015; 68:464-70.

[4] Stattin P, Vickers AJ, Sjoberg DD, et al. Improving the Specificity of Screening for Lethal Prostate Cancer Using Prostate-specific Antigen and a Panel of Kallikrein Markers: A Nested Case-Control Study. Euro Urol. 2015; 68:207-213.

[5] Konety B, Zappala SM, Parekh DJ, et al. The 4Kscore® Test Reduces Prostate Biopsy Rates in Community and Academic Urology Practices. Rev Urol. 2015; 17(4):231-40.


How the 4Kscore® Test is Helping Reduce Unnecessary Prostate Biopsies

According to the American Cancer Society, there will be roughly 160,000 new cases of prostate cancer diagnosed in the US this year alone, with over 26,000 deaths estimated from this disease. [1] It is essential that aggressive forms of prostate cancer, that are more likely to spread and lead to death, are diagnosed early when they may still be treatable.  Traditionally this has been done through screening with PSA, followed by a prostate biopsy for men with an abnormal result. Unfortunately, in many cases PSA is elevated in men without prostate cancer.  As a result, there are many unnecessary prostate biopsies, which has led to a push to reduce or eliminate prostate cancer screening.

The PSA Dilemma

The PSA test is a widely used blood screening test for prostate cancer, that measures the amount of prostate-specific antigen (PSA).  During the time since its widespread adoption, there has been a significant reduction in metastasis and death due to prostate cancer.  However, most men getting a prostate biopsy after screening with PSA will not have aggressive prostate cancer, and many will not have any cancer at all.  Due to the complications associated with prostate biopsy, including hospitalization, bleeding, sepsis, and pain, it is important to reduce the number of unnecessary biopsies done. [2, 3, 4] There is a clear need to both continue to find men with a higher risk for aggressive prostate cancer early, and reduce biopsies in men with a low risk.

The True Cost of Unnecessary Prostate Biopsy

Unnecessary prostate biopsies include a range of medical expenses due to procedural and diagnostic costs, but the true cost reaches beyond that. Patients and their families experience anxiety around the side effects of prostate biopsies, as well as the fear of the detection of cancer.  The harms from over-diagnosis and over-treatment of benign conditions and indolent prostate cancer can be very significant.

4Kscore & the Prostate Biopsy Decision

The 4Kscore Test is a simple blood test, used after an abnormal PSA, that reduces unnecessary prostate biopsies by providing the risk of aggressive prostate cancer before a biopsy decision is made.  It measures four prostate-specific proteins in the blood: Total PSA, Free PSA, Intact PSA, and Human Kallikrein 2 (hK2), and combines them with clinical findings (age, prior biopsy history, and optionally a digital rectal examination) to provide a risk score. By asking for a 4Kscore test, men and their physicians can make a biopsy decision knowing the personal risk for aggressive prostate cancer, and avoid unnecessary procedures in low risk men.

At BioReference, we are committed to helping reduce the number of unnecessary biopsies performed annually, while helping men at high risk get the proper evaluation they need. If you, or a loved one, have recently received news of an abnormal PSA score, we encourage you to speak to your doctor about undergoing a 4Kscore Test. If you are a physician interested in offering the 4Kscore Test in your practice, we encourage you to contact us today. Learn more about how this simple blood test is helping to reduce unnecessary biopsies.

If you are interested in learning more about prostate health, follow our blog and connect with us on Facebook, Twitter, Google+ and LinkedIn.

  • American Cancer Society. Key Statistics for Prostate Cancer. (Access June 12, 2017)
  • National Cancer Institute. Prostate-Specific Antigen (PSA) Test. (Access June 12, 2017)
  • Parekh DJ, Punnen Sm, Sjoberg DDm et al. A Multi-institutional Prospective Trial in the USA Confirms that the 4Kscore Accurately Identifies Men with High-grade Prostate Cancer. Eur Urol. 2015; 68:464-70.
  • Liss, M. A., et al. (2017). “An Update of the American Urological Association White Paper on the Prevention and Treatment of the More Common Complications Related to Prostate Biopsy.” J Urol.

Tips for Staying Active on Vacation

Preparing for a much-anticipated vacation? When planning a trip, it can be easy to get caught up in all of the excitement and neglect to account for your fitness routine. However, vacation is the perfect time to take your fitness regime to the next level. As you pack for that getaway in the mountains or escape to the beach, be sure to remember your hiking or running shoes. Not convinced that summer vacation is the time to prioritize your health? Consider this:

Physical Activity and Heath Risk

While most of us understand that regular physical activity contributes to our long-term health, did you know that recent research indicates a link between regular physical activity and a reduced risk of certain types of cancers? [1] Researchers at the University of Vermont, Burlington concluded that physically fit men, in their midlife, are at a reduced risk level of cancer-related death as they age. [2]. Additionally, there is some evidence that increased activity in men who have been diagnosed with prostate cancer may lead to improved outcomes[3] Simply put, staying fit just makes sense for your long-term health. What better time to prioritize your health than when you have extra leisure time on your hands?

  • Take a Hike
    No matter where your summer travels take you, chances are there is a hiking trailhead nearby. Check out the local tourism board’s website or ask locals for tips on popular hikes in the area. No matter your fitness level, you can find a hike that will challenge you and give you an energy boost for the rest of the day. Make it a point to check out a variety of trails, you are sure to enjoy taking in your vacation destination from this vantage point.
  • Take a Walking Tour
    Taking a simple walk can do wonders for your health. According to the US Department of Health and Human Services and the American Cancer Society, adults should get at least two and a half hours of moderate intensity exercise, such as walking, each week, or one and a quarter hours of vigorous intensity exercise each week. Research found that those who achieve this level activity, lowered their risk of death by 31%, while those who got 3 to 5 times the recommended amount lowered their risk of death by 39%. [4] Looking into guided walking tours while on your vacation destination can be a great way to get in some exercise while taking in the sights and sounds of your surroundings.
  • Get in a Workout Before You Start Your Day
    If you prefer to get in your workout early in the day, consider some circuit training. If you have a gym available to you, take advantage of it. Otherwise use the space available to get your metabolism moving. Jumping jacks, pushups and squats are just a few examples of exercises you can complete in a small space without the need for equipment. Get creative and start your day off on the right foot.

Rather than allowing your fitness routine to take a backseat during your next vacation this summer, why not make it a priority? Your body will thank you for it. If you are not currently active and are ready to get back into shape, use your time away as an opportunity to kick-start a new routine, and take the steps today to ensure your long-term health.
Would you like to receive more tips and insight on living a healthy lifestyle? Subscribe to our blog and follow us on Facebook, Twitter, Google+ and LinkedIn!


1) National Cancer Institute. Physical Activity and Cancer. Available at (Accessed June 27, 2016)
2) JAMA Oncology. Midlife Cardiorespiratory Fitness, Incident Cancer, and Survival After Cancer in Men. Available at (Accessed June 27, 2016)
3) National Cancer Institute. Physical Activity and Cancer. Available at (Accessed June 27, 2016)
4) American Cancer Society. Study Shows Walking an Hour a Day Achieves Greatest Longevity Benefit. Available at (Accessed July 20, 2017)

A Father’s Day Gift for the Special Dad in Your Life

Are you struggling to think of the ideal Father’s Day gift? This time of year, many of us are faced with the challenge of finding a gift that expresses our love and gratitude for the special fathers in our lives. If you are once again facing this dilemma, why not give peace of mind for their prostate health with information about the 4Kscore this Father’s Day.

Prostate Cancer Risk

Prostate cancer is the second most common type of cancer in men, second only to skin cancer. It is estimated that 161,360 men in the US will be diagnosed with the disease this year and it will lead to 26,730 deaths. [1] Though prostate cancer is one of the most common types of cancer in men, the number of deaths from the disease in the US continues to decline. [1] This is welcome news to the loved ones of the men diagnosed with this disease.  This highlights the need to continue screening for prostate cancer with PSA, and providing those men who have an abnormal PSA with their risk of aggressive prostate cancer with a test such as 4Kscore. If you, or a loved one, are considered high risk, the 4Kscore can provide peace of mind to those who matter most.

The 4Kscore® Test

The 4Kscore is a simple blood test that helps doctors and patients in the biopsy decision-making process. The 4Kscore determines a patient’s probability for having aggressive prostate cancer upon biopsy. To arrive at a patient’s 4Kscore, a blood sample is evaluated to measure four prostate-specific kallikreins in the blood: Total PSA, Free PSA, Intact PSA, and Human Kallikrein 2 (hK2). The results of the blood test, along with clinical findings, are then analyzed in an algorithm to arrive at the patient’s personal risk percent from <1% to >95% of having aggressive cancer in a biopsy.

Give the Gift of Peace of Mind this Father’s Day

Rather than giving the special dads in your life another gadget this year, give the gift of prostate health peace of mind with information about prostate cancer risk and the 4Kscore test. Download our brochure and encourage him to contact this physician and ask the right questions. If his physician believes the 4Kscore test is right for him and orders the 4Kscore test, he can have his blood drawn at a 4Kscore patient service center.

On behalf of all of us at BioReference, we wish you and your family a very Happy Father’s Day!

Would you like to receive more insight and information on prostate health throughout the year? Subscribe to our blog!

  • Prostate Cancer: Statistics. Available (Accessed May 30, 2017).

Celebrate Men’s Health Month With Us

As you know, June is Men’s Health Month – a time we consider to be the perfect opportunity to do our part to shed light on the health issues that men face each and every day. To celebrate, we are hosting a #KnowYourScore Sweepstakes.


Just like any sports fan or athlete knows, the score is important to the game. So why, in a time where prostate cancer is the second most common cause of cancer death in men, is knowing your score for aggressive prostate cancer not just as important?

For men who have had an abnormal PSA test result, the 4Kscore delivers an individual man’s percent risk of aggressive prostate cancer ranging from <1% to >95% if a prostate biopsy were performed. However, many men may not understand their test result numbers and what they mean with regards to their risk of disease. That is why we are encouraging men to #KnowYourScore and talk with their physicians about what it means to them.

Win a Prize During Men’s Health Month

To help raise awareness during Men’s Health Month and encourage men to #KnowYourScore, we’re pleased to announce another #KnowYourScore sweepstakes.

Click here to join our mailing list to receive information about aggressive prostate cancer and other diseases that impact the men you love, and you will be automatically entered into the sweepstakes. One lucky entrant will be chosen at random to win a prize, which have been hand-selected to ‘keep you in the game’ this season.

Celebrate with Us

If you are a man with an abnormal PSA result, take the time during Men’s Health Month this June to talk with your doctor about your prostate cancer health, and see if you are a candidate for the 4Kscore test. Know your results and #KnowYourScore.

If you want to help the other men in your life #KnowYourScore, join the conversation online and help us spread the word about prostate cancer testing. Subscribe to our blog and follow us on Facebook, Twitter, Google+ and LinkedIn.


Happy Men’s Health Month

Happy Men’s Health Month. Here at BioReference, we consider this annual observance to be the perfect opportunity to do our part to shed light on the health issues that men face each and every day. The purpose of Men’s Health Month is to raise awareness about the preventable health issues that both men and boys face and to encourage early detection and treatment. Men’s Health Week was first proposed in 1994 as a Congressional health education program. Celebrated nationwide, there is now an  entire month dedicated to this observance which has grown in popularity year over year since its inception.

How to Get Involved

Anchored by a Congressional health education program, Men’s Health Month is intended to provide a platform for individuals, members of the media, health care providers and public policy makers to share dialog about the health concerns that impact the male population. If you would like to do your part to get involved in Men’s Health Month, we encourage you to visit the official website for more details.

Men’s Health Issues

Why is this observance so important? Education is our very best defense against many of the health issues that men face.

  • Women are 100% likely to visit the doctor for preventive services and annual exams. [1]
  • In 1920, women lived on average of 1 year longer than men. Today, women outlive men by an average of 5 years. [1]
  • 1 in 7 men will be diagnosed with prostate cancer in their lifetime. [2]
  • Roughly 1 man in 39 will die of prostate cancer. [2]
  • Heart disease and cancer are the leading causes of death in men. [1]

The 4Kscore® Test and Early Prostate Cancer Detection

At BioReference Laboratories we proudly stand behind the message of Men’s Health Month. As the makers of the 4Kscore Test, a simple blood test that helps to clarify the biopsy decision-making process after an abnormal PSA, we work year-round to shed light on the importance of early prostate cancer detection. The 4Kscore Test predicts a man’s risk percentage of having aggressive prostate cancer on a scale of <1% to >95%, using an algorithm that includes four prostate-specific kallikreins in the blood: Total PSA, Free PSA, Intact PSA, and Human Kallikrein 2 (hK2), along with clinical findings.

Celebrate Men’s Health Month & Determine Your 4Kscore

We encourage you to celebrate Men’s Health Month in your own way and to use this annual observance as a reminder to remain vigilant about undergoing regular health screenings. If you, or a loved one, have not been screened recently for prostate cancer, we urge you to talk to your doctor about the 4Kscore Test, and stay tuned next week for other ways to celebrate with us.

If you are interested in learning more about prostate health and the 4Kscore Test, subscribe to our blog and follow us on Facebook, Twitter, Google+ and LinkedIn. Connect with us today.


  1. Men’s Health Network. Men’s Health Facts. Available at (Accessed May 30, 2017).
  2. American Cancer Society. Key Statistics for Prostate Cancer. Available at (Accessed May 30, 2017).


Who is the Ideal Candidate for the 4Kscore Test?

The 4Kscore is a simple blood test which analyzes four prostate-specific biomarkers in the blood along with clinical information. The results of the 4Kscore Test provide each patient with a personalized, accurate measurement of their risk for having aggressive prostate cancer; information which can be used to help in the biopsy decision making process.

Are you a candidate for the 4Kscore Test?

For many years, doctors and patients relied on the PSA test when considering a prostate biopsy. However, PSA results alone do not clearly distinguish between the risk of aggressive prostate cancer and other less serious health conditions. All too often, abnormal PSA results have lead to unnecessary prostate biopsies and treatments, the results of which can have serious side effects.

If you, or a loved one, have recently received news of an abnormal PSA score, chances are you’re looking for answers. Because an abnormal PSA score is not necessarily specific for aggressive prostate cancer, it is important to learn more about your personal risk. Men with an abnormal screening test result, such as PSA, are candidates for the 4Kscore Test. Together a patient and his physician can use the 4Kscore to help determine whether or not he should undergo a prostate biopsy.

Evaluating the risk for aggressive prostate cancer

The 4Kscore helps men identify their risk for high grade prostate cancer. The stress associated with undergoing a prostate biopsy, in addition to the potential complications, make it critical for medical professionals to be able to differentiate between low risk and high risk patients. The 4Kscore Test is helping to do just that. Patients at low risk can avoid unnecessary medical procedures and those at high risk can be identified and recieve appropriate follow-up.

If you believe that you, or a loved one, are a candidate for the 4Kscore test, we encourage you to speak to your doctor. If your doctor orders the 4Kscore test for you, you can find a 4Kscore test blood draw site in your area. If you are a physician interested in offering the 4Kscore Test, we encourage you to contact us today. Learn more about how this simple blood test is helping to clarify the biopsy decision making process.

If you are interested in learning more about prostate health, follow our blog and connect with us on Facebook, Twitter, Google+ and LinkedIn.