Evaluation of prostate cancer risk using PSA has resulted in many unnecessary prostate biopsies with their attendant complications, follow up tests, and treatments, many of which are done on men with indolent or no prostate cancer. In a clinical utility study, the use of the 4Kscore Test after an abnormal PSA and/or DRE led to a 64.6% reduction in prostate biopsies, with a 94% reduction in low risk men. Utilization of the 4Kscore Test can reduce the costs associated with prostate cancer evaluation and treatment for health plans and employer groups by a significant amount, while continuing to identify men at a higher risk of aggressive prostate cancer for further evaluation.
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1. Konety, B., Zappala, S., Parekh, D., et al. “The 4Kscore® Test Reduces Prostate Biopsy Rates in Community and Academic Urology Practices.” Reviews in urology 17.4 (2015): 231.