What is the 4Kscore Test

The 4Kscore test is a non‐invasive blood based test that provides a second decision point prior to a prostate biopsy after an abnormal PSA and/or digital rectal examination. It provides an accurate risk of aggressive prostate cancer, allowing for early detection of high risk men, while reducing the number of unnecessary prostate biopsies.[1] It has been shown to categorize long term risk of distant metastasis in men with an elevated PSA, and is included in NCCN guidelines for Prostate Cancer Early Detection.[2] Use of the 4Kscore will reduce the costs and complications of unnecessary prostate biopsies, while identifying men at a higher risk of aggressive cancer, who would benefit from more extensive evaluation.[3]

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Learn how the 4Kscore measures a patient’s risk for aggressive prostate cancer

1. Parekh DJ, Punnen S, Sjoberg DD, et al. A multi‐institutional prospective trial in the USA confirms that the 4Kscore accurately identifies men with high‐grade prostate cancer. Eur Urol. 2015 Sep;68(3):464‐70.
2. Stattin P, Vickers AJ, Sjoberg DD et al. Improving the specificity of screening for lethal prostate cancer using prostate‐specific antigen and a panel of kallikrein markers: a nested case–control study. Eur Urol. 2015 Aug;68(2):207‐13.
3. Konety, B., Zappala, S., Parekh, D., et al. “The 4Kscore® Test Reduces Prostate Biopsy Rates in Community and Academic Urology Practices.” Reviews in urology 17.4 (2015): 231.